This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for AKIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:8,671,011–8,671,925 | 239.8 kb | Distal (>10kb) Multiome | 223 | |
| chr11:8,682,170–8,683,291 | 228.5 kb | Distal (>10kb) Multiome | 956 | |
| chr11:8,687,635–8,689,327 | 222.2 kb | Distal (>10kb) Multiome | 1023 | |
| chr11:8,700,857–8,701,532 | 209.9 kb | Distal (>10kb) Multiome | 216 | |
| chr11:8,713,673–8,714,258 | 197.3 kb | Distal (>10kb) Multiome HiCAR | 102 | |
| chr11:8,800,375–8,801,511 | 110.2 kb | Distal (>10kb) Multiome | 167 | |
| chr11:8,810,380–8,811,275 | 100.5 kb | Distal (>10kb) Multiome | 360 | |
| chr11:8,813,629–8,814,688 | 97.3 kb | Distal (>10kb) Multiome | 380 | |
| chr11:8,870,357–8,871,640 | 40.3 kb | Distal (>10kb) Multiome | 506 | |
| chr11:8,909,732–8,910,606 | 591 bp | At TSS | 128 | |
| chr11:8,910,714–8,911,839 | 23 bp | At TSS Multiome | 722 | |
| chr11:8,963,907–8,965,344 | 53.2 kb | Distal (>10kb) Multiome | 912 | |
| chr11:9,003,516–9,004,824 | 92.9 kb | Distal (>10kb) Multiome | 534 | |
| chr11:9,090,882–9,091,926 | 180.3 kb | Distal (>10kb) Multiome | 196 |
Genomic view of the AKIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.