Enables AMP binding activity and nucleobase-containing compound kinase activity. Predicted to be involved in nucleoside monophosphate phosphorylation. Predicted to act upstream of or within ventricular system development. Located in 9+2 motile cilium. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for AK8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AK8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AK8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:132,582,095–132,582,589 | 296.0 kb | Distal (>10kb) Multiome | 938 | |
| chr9:132,794,730–132,795,358 | 83.3 kb | Distal (>10kb) Multiome | 159 | |
| chr9:132,877,859–132,878,978 | 138 bp | At TSS Multiome | 676 | |
| chr9:132,944,084–132,945,377 | 66.5 kb | Distal (>10kb) Multiome | 983 | |
| chr9:133,030,039–133,031,100 | 152.4 kb | Distal (>10kb) Multiome | 998 | |
| chr9:133,059,688–133,060,833 | 182.2 kb | Distal (>10kb) Multiome | 222 | |
| chr9:133,120,589–133,121,652 | 243.0 kb | Distal (>10kb) Multiome | 599 | |
| chr9:133,144,161–133,144,920 | 266.3 kb | Distal (>10kb) Multiome | 776 | |
| chr9:133,147,412–133,149,938 | 271.1 kb | Distal (>10kb) Multiome | 979 | |
| chr9:133,163,575–133,164,128 | 285.6 kb | Distal (>10kb) Multiome | 308 |
Genomic view of the AK8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.