This gene encodes a member of the adenylate kinase family of enzymes. The encoded enzyme is a phosphotransferase that catalyzes the reversible phosphorylation of adenine nucleotides. This enzyme plays a role in energy homeostasis of the cell. Alternative splicing results in multiple transcript variants. Mutations in the mouse gene are associated with primary ciliary dyskinesia. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for AK7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AK7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AK7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:96,191,842–96,192,712 | 199.9 kb | Distal (>10kb) Multiome | 49 | |
| chr14:96,362,703–96,364,312 | 28.7 kb | Distal (>10kb) Multiome | 728 | |
| chr14:96,391,216–96,392,835 | 190 bp | At TSS Multiome | 787 | |
| chr14:96,461,283–96,462,546 | 69.9 kb | Distal (>10kb) Multiome | 392 | |
| chr14:96,501,754–96,503,092 | 110.2 kb | Distal (>10kb) Multiome | 986 | |
| chr14:96,583,910–96,584,894 | 192.3 kb | Distal (>10kb) Multiome | 345 | |
| chr14:96,592,395–96,593,217 | 200.6 kb | Distal (>10kb) Multiome | 226 | |
| chr14:96,665,756–96,666,415 | 274.0 kb | Distal (>10kb) Multiome | 41 |
Genomic view of the AK7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.