Enables alpha-catenin binding activity and transcription corepressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of hippo signaling; and regulation of cellular response to hypoxia. Acts upstream of or within miRNA-mediated post-transcriptional gene silencing and positive regulation of protein-containing complex assembly. Located in several cellular components, including Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AJUBA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AJUBA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AJUBA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,766,419–22,767,375 | 215.9 kb | Distal (>10kb) Multiome | 988 | |
| chr14:22,821,826–22,823,530 | 159.7 kb | Distal (>10kb) Multiome | 649 | |
| chr14:22,829,704–22,830,328 | 152.6 kb | Distal (>10kb) Multiome | 871 | |
| chr14:22,836,107–22,837,017 | 146.1 kb | Distal (>10kb) Multiome | 320 | |
| chr14:22,852,845–22,853,709 | 129.3 kb | Distal (>10kb) Multiome | 788 | |
| chr14:22,870,967–22,873,202 | 111.0 kb | Distal (>10kb) Multiome | 1167 | |
| chr14:22,882,594–22,883,886 | 99.4 kb | Distal (>10kb) Multiome | 289 | |
| chr14:22,886,371–22,887,824 | 95.4 kb | Distal (>10kb) Multiome | 639 | |
| chr14:22,918,527–22,919,975 | 63.2 kb | Distal (>10kb) Multiome | 641 | |
| chr14:22,928,961–22,930,849 | 53.0 kb | Distal (>10kb) Multiome | 1108 | |
| chr14:22,956,530–22,957,512 | 25.5 kb | Distal (>10kb) Multiome | 983 | |
| chr14:22,973,681–22,973,857 | 8.7 kb | Proximal (<10kb) | 277 | |
| chr14:22,976,871–22,978,437 | 4.1 kb | Proximal (<10kb) | 680 | |
| chr14:22,980,658–22,980,953 | 1.6 kb | Proximal (<10kb) | 399 | |
| chr14:22,981,215–22,983,249 | 140 bp | At TSS Multiome | 935 | |
| chr14:22,983,367–22,983,566 | 816 bp | At TSS | 271 | |
| chr14:22,986,661–22,986,881 | 4.1 kb | Proximal (<10kb) | 308 | |
| chr14:23,006,674–23,007,583 | 24.6 kb | Distal (>10kb) Multiome | 1097 | |
| chr14:23,020,642–23,021,291 | 38.4 kb | Distal (>10kb) Multiome HiCAR | 148 | |
| chr14:23,101,326–23,101,861 | 119.1 kb | Distal (>10kb) Multiome | 83 | |
| chr14:23,182,495–23,182,942 | 200.2 kb | Distal (>10kb) Multiome | 139 | |
| chr14:23,237,732–23,238,192 | 255.4 kb | Distal (>10kb) Multiome | 536 |
Genomic view of the AJUBA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.