Enables arginase activity; guanidinobutyrase activity; and guanidinopropionase activity. Predicted to be involved in putrescine biosynthetic process from arginine, via agmatine. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AGMAT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGMAT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGMAT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:15,409,150–15,410,227 | 175.2 kb | Distal (>10kb) Multiome | 618 | |
| chr1:15,523,864–15,525,570 | 60.5 kb | Distal (>10kb) Multiome | 674 | |
| chr1:15,526,118–15,527,442 | 58.2 kb | Distal (>10kb) Multiome | 899 | |
| chr1:15,584,405–15,585,197 | 281 bp | At TSS Multiome | 693 | |
| chr1:15,593,509–15,593,714 | 8.5 kb | Proximal (<10kb) | 8 | |
| chr1:15,603,163–15,603,936 | 18.6 kb | Distal (>10kb) Multiome | 795 | |
| chr1:15,616,785–15,618,260 | 32.3 kb | Distal (>10kb) Multiome | 909 | |
| chr1:15,741,258–15,741,859 | 156.5 kb | Distal (>10kb) Multiome | 436 | |
| chr1:15,757,615–15,759,609 | 173.5 kb | Distal (>10kb) Multiome | 439 | |
| chr1:15,834,229–15,836,682 | 249.8 kb | Distal (>10kb) Multiome | 1154 | |
| chr1:15,847,036–15,848,900 | 262.6 kb | Distal (>10kb) Multiome | 817 | |
| chr1:15,849,314–15,850,241 | 264.7 kb | Distal (>10kb) Multiome | 788 |
Genomic view of the AGMAT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.