This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for AGBL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGBL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGBL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:26,764,126–26,764,575 | 287.4 kb | Distal (>10kb) Multiome | 781 | |
| chr2:26,785,402–26,786,601 | 265.8 kb | Distal (>10kb) Multiome | 996 | |
| chr2:26,846,388–26,846,855 | 205.2 kb | Distal (>10kb) Multiome | 343 | |
| chr2:26,847,436–26,849,494 | 203.7 kb | Distal (>10kb) Multiome | 447 | |
| chr2:26,961,589–26,962,066 | 89.8 kb | Distal (>10kb) Multiome | 502 | |
| chr2:26,970,294–26,971,331 | 81.1 kb | Distal (>10kb) Multiome | 572 | |
| chr2:27,032,577–27,033,271 | 18.8 kb | Distal (>10kb) Multiome | 799 | |
| chr2:27,049,564–27,052,299 | 908 bp | At TSS Multiome | 1295 | |
| chr2:27,071,223–27,072,896 | 20.1 kb | Distal (>10kb) Multiome | 864 | |
| chr2:27,081,006–27,081,641 | 29.7 kb | Distal (>10kb) Multiome | 758 | |
| chr2:27,085,591–27,087,452 | 35.0 kb | Distal (>10kb) Multiome | 970 | |
| chr2:27,123,498–27,124,089 | 72.1 kb | Distal (>10kb) Multiome | 553 | |
| chr2:27,133,917–27,135,216 | 83.0 kb | Distal (>10kb) Multiome | 815 | |
| chr2:27,211,255–27,212,840 | 160.4 kb | Distal (>10kb) Multiome | 978 | |
| chr2:27,217,045–27,218,005 | 165.7 kb | Distal (>10kb) Multiome | 771 | |
| chr2:27,250,040–27,250,883 | 198.7 kb | Distal (>10kb) Multiome | 559 | |
| chr2:27,262,260–27,263,337 | 211.2 kb | Distal (>10kb) Multiome | 376 | |
| chr2:27,264,406–27,265,326 | 213.4 kb | Distal (>10kb) Multiome | 696 | |
| chr2:27,306,488–27,307,261 | 255.0 kb | Distal (>10kb) Multiome | 115 | |
| chr2:27,322,773–27,323,423 | 271.4 kb | Distal (>10kb) Multiome | 906 |
Genomic view of the AGBL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.