Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013]
Transcription factors with Perturb-seq knockdown data for AGBL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGBL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGBL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:85,793,725–85,795,403 | 284.9 kb | Distal (>10kb) Multiome | 616 | |
| chr15:85,840,188–85,840,902 | 239.2 kb | Distal (>10kb) Multiome | 709 | |
| chr15:86,284,444–86,285,083 | 204.9 kb | Distal (>10kb) Multiome | 95 | |
| chr15:86,892,085–86,893,378 | 812.9 kb | Distal (>10kb) Multiome | 338 | |
| chr15:87,038,028–87,039,006 | 958.7 kb | Distal (>10kb) Multiome | 142 |
Genomic view of the AGBL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.