The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for AGAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,727,450–57,727,983 | 9.9 kb | Proximal (<10kb) | 164 | |
| chr12:57,735,954–57,736,261 | 1.6 kb | Proximal (<10kb) | 356 | |
| chr12:57,737,534–57,738,406 | at TSS | At TSS | 237 | |
| chr12:57,738,612–57,739,176 | 776 bp | At TSS | 201 | |
| chr12:57,742,146–57,742,369 | 4.3 kb | Proximal (<10kb) | 170 | |
| chr12:57,744,434–57,745,735 | 6.6 kb | Proximal (<10kb) | 822 |
Genomic view of the AGAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.