Predicted to enable 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; manganese ion binding activity; and pyrophosphatase activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ADPRM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADPRM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADPRM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:10,697,052–10,698,025 | 8 bp | At TSS Multiome | 852 | |
| chr17:10,729,418–10,730,194 | 32.3 kb | Distal (>10kb) Multiome | 604 | |
| chr17:10,754,906–10,755,615 | 57.7 kb | Distal (>10kb) Multiome | 62 | |
| chr17:10,844,622–10,845,447 | 147.6 kb | Distal (>10kb) Multiome | 298 | |
| chr17:10,936,641–10,937,774 | 239.6 kb | Distal (>10kb) Multiome | 142 | |
| chr17:11,598,120–11,599,444 | 901.4 kb | Distal (>10kb) Multiome HiCAR | 315 | |
| chr17:11,986,045–11,987,265 | 1288.8 kb | Distal (>10kb) Multiome HiCAR | 204 |
Genomic view of the ADPRM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.