ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ADPRHL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADPRHL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADPRHL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:113,152,885–113,154,060 | 300.2 kb | Distal (>10kb) Multiome | 714 | |
| chr13:113,208,078–113,210,214 | 244.0 kb | Distal (>10kb) Multiome | 1103 | |
| chr13:113,296,598–113,297,816 | 156.3 kb | Distal (>10kb) Multiome | 1104 | |
| chr13:113,393,735–113,394,451 | 59.4 kb | Distal (>10kb) Multiome | 576 | |
| chr13:113,450,986–113,451,144 | 2.3 kb | Proximal (<10kb) | 24 | |
| chr13:113,489,310–113,491,886 | 37.5 kb | Distal (>10kb) Multiome | 791 | |
| chr13:113,584,313–113,585,542 | 131.2 kb | Distal (>10kb) Multiome | 559 |
Genomic view of the ADPRHL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.