Transcription factors with Perturb-seq knockdown data for ADM-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADM-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADM-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:10,293,485–10,294,954 | 8.7 kb | Proximal (<10kb) | 728 | |
| chr11:10,302,521–10,303,802 | at TSS | At TSS | 595 | |
| chr11:10,303,927–10,306,992 | 223 bp | At TSS | 897 | |
| chr11:10,307,252–10,308,323 | 3.5 kb | Proximal (<10kb) | 800 | |
| chr11:10,309,037–10,310,838 | 5.3 kb | Proximal (<10kb) | 494 |
Genomic view of the ADM-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.