The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Transcription factors with Perturb-seq knockdown data for ADM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:9,613,193–9,614,617 | 690.9 kb | Distal (>10kb) Multiome HiCAR | 997 | |
| chr11:9,757,927–9,759,329 | 546.8 kb | Distal (>10kb) Multiome HiCAR | 865 | |
| chr11:10,293,485–10,294,954 | 11.0 kb | Distal (>10kb) Multiome | 728 | |
| chr11:10,302,521–10,303,802 | 1.3 kb | Proximal (<10kb) | 595 | |
| chr11:10,303,927–10,306,992 | 141 bp | At TSS Multiome | 897 | |
| chr11:10,307,252–10,308,323 | 2.9 kb | Proximal (<10kb) Multiome | 800 | |
| chr11:10,309,037–10,310,838 | 4.6 kb | Proximal (<10kb) Multiome | 494 | |
| chr11:10,351,409–10,352,676 | 46.9 kb | Distal (>10kb) Multiome | 677 | |
| chr11:10,450,400–10,451,424 | 146.0 kb | Distal (>10kb) Multiome | 419 | |
| chr11:10,455,858–10,456,376 | 151.0 kb | Distal (>10kb) Multiome | 394 | |
| chr11:10,540,488–10,541,619 | 236.1 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the ADM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.