Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ADGRG7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADGRG7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADGRG7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:100,334,205–100,335,290 | 274.9 kb | Distal (>10kb) Multiome HiCAR | 849 | |
| chr3:100,400,431–100,402,077 | 208.3 kb | Distal (>10kb) Multiome | 977 | |
| chr3:100,491,845–100,493,045 | 117.2 kb | Distal (>10kb) Multiome | 816 | |
| chr3:100,601,812–100,603,934 | 7.2 kb | Proximal (<10kb) Multiome | 474 | |
| chr3:100,653,860–100,654,199 | at TSS | At TSS | 20 | |
| chr3:100,657,009–100,657,496 | 2.8 kb | Proximal (<10kb) | 20 | |
| chr3:100,708,973–100,710,881 | 99.9 kb | Distal (>10kb) Multiome | 882 | |
| chr3:100,737,208–100,738,101 | 128.0 kb | Distal (>10kb) Multiome | 200 |
Genomic view of the ADGRG7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.