This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for ADGRG5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADGRG5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADGRG5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:57,244,660–57,245,782 | 297.5 kb | Distal (>10kb) Multiome | 949 | |
| chr16:57,284,181–57,285,057 | 258.0 kb | Distal (>10kb) Multiome | 883 | |
| chr16:57,299,458–57,301,365 | 242.7 kb | Distal (>10kb) Multiome | 1112 | |
| chr16:57,416,668–57,417,660 | 125.5 kb | Distal (>10kb) Multiome | 597 | |
| chr16:57,446,894–57,447,991 | 95.2 kb | Distal (>10kb) Multiome | 958 | |
| chr16:57,475,764–57,476,257 | 66.7 kb | Distal (>10kb) Multiome | 391 | |
| chr16:57,485,922–57,486,831 | 56.1 kb | Distal (>10kb) Multiome | 527 | |
| chr16:57,528,258–57,529,545 | 13.9 kb | Distal (>10kb) Multiome | 230 | |
| chr16:57,535,588–57,536,986 | 6.5 kb | Proximal (<10kb) Multiome | 726 | |
| chr16:57,600,258–57,600,842 | 57.9 kb | Distal (>10kb) Multiome | 438 | |
| chr16:57,734,819–57,736,404 | 192.9 kb | Distal (>10kb) Multiome | 885 | |
| chr16:57,757,066–57,757,860 | 214.7 kb | Distal (>10kb) Multiome | 470 | |
| chr16:57,774,953–57,776,466 | 233.3 kb | Distal (>10kb) Multiome | 273 | |
| chr16:57,801,721–57,803,781 | 259.8 kb | Distal (>10kb) Multiome | 918 |
Genomic view of the ADGRG5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.