This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for ADGRE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADGRE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADGRE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:14,495,705–14,496,690 | 280.5 kb | Distal (>10kb) Multiome | 813 | |
| chr19:14,517,523–14,519,160 | 258.2 kb | Distal (>10kb) Multiome | 952 | |
| chr19:14,528,857–14,530,279 | 247.3 kb | Distal (>10kb) Multiome | 842 | |
| chr19:14,536,700–14,537,683 | 239.6 kb | Distal (>10kb) Multiome | 329 | |
| chr19:14,564,060–14,565,155 | 212.3 kb | Distal (>10kb) Multiome | 226 | |
| chr19:14,571,772–14,572,330 | 204.7 kb | Distal (>10kb) Multiome | 896 | |
| chr19:14,689,407–14,690,497 | 86.8 kb | Distal (>10kb) Multiome | 624 | |
| chr19:14,776,664–14,776,846 | at TSS | At TSS | 193 | |
| chr19:14,786,377–14,786,738 | 9.6 kb | Proximal (<10kb) | 224 | |
| chr19:14,979,199–14,980,219 | 203.1 kb | Distal (>10kb) Multiome | 147 | |
| chr19:15,010,607–15,011,356 | 234.2 kb | Distal (>10kb) Multiome | 122 |
Genomic view of the ADGRE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.