This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for ADGRB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADGRB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADGRB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:31,548,778–31,549,765 | 215.2 kb | Distal (>10kb) Multiome | 641 | |
| chr1:31,617,603–31,618,426 | 146.1 kb | Distal (>10kb) Multiome | 345 | |
| chr1:31,644,333–31,645,606 | 119.4 kb | Distal (>10kb) Multiome | 926 | |
| chr1:31,703,931–31,704,503 | 60.2 kb | Distal (>10kb) Multiome | 217 | |
| chr1:31,714,302–31,716,109 | 49.1 kb | Distal (>10kb) Multiome | 759 | |
| chr1:31,760,521–31,761,442 | 3.4 kb | Proximal (<10kb) Multiome | 317 | |
| chr1:31,762,648–31,763,343 | 1.5 kb | Proximal (<10kb) Multiome | 402 | |
| chr1:31,764,083–31,764,672 | 67 bp | At TSS Multiome | 263 | |
| chr1:31,769,677–31,770,397 | 5.6 kb | Proximal (<10kb) | 185 | |
| chr1:31,788,126–31,789,694 | 25.1 kb | Distal (>10kb) Multiome | 713 | |
| chr1:31,815,736–31,816,251 | 51.7 kb | Distal (>10kb) Multiome | 666 | |
| chr1:31,937,587–31,938,944 | 174.1 kb | Distal (>10kb) Multiome | 1111 | |
| chr1:31,943,994–31,945,090 | 180.2 kb | Distal (>10kb) Multiome | 826 | |
| chr1:31,964,141–31,964,595 | 199.9 kb | Distal (>10kb) Multiome | 529 | |
| chr1:32,013,168–32,015,085 | 249.3 kb | Distal (>10kb) Multiome | 988 |
Genomic view of the ADGRB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.