This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for ADCY3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADCY3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADCY3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:24,792,642–24,794,076 | 126.9 kb | Distal (>10kb) Multiome | 1010 | |
| chr2:24,821,671–24,822,465 | 98.0 kb | Distal (>10kb) Multiome | 172 | |
| chr2:24,827,474–24,828,282 | 92.4 kb | Distal (>10kb) Multiome | 460 | |
| chr2:24,919,504–24,920,824 | 28 bp | At TSS Multiome | 431 | |
| chr2:24,971,247–24,972,384 | 51.7 kb | Distal (>10kb) Multiome | 1032 | |
| chr2:25,041,314–25,043,455 | 121.8 kb | Distal (>10kb) Multiome | 743 | |
| chr2:25,131,383–25,132,709 | 212.1 kb | Distal (>10kb) Multiome | 162 | |
| chr2:25,161,156–25,161,629 | 241.2 kb | Distal (>10kb) Multiome | 112 | |
| chr2:25,168,208–25,168,958 | 248.4 kb | Distal (>10kb) Multiome | 225 | |
| chr2:25,215,506–25,216,577 | 295.9 kb | Distal (>10kb) Multiome | 303 |
Genomic view of the ADCY3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.