Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in negative regulation of mitochondrial fusion and positive regulation of cristae formation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ADCK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADCK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADCK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:77,615,862–77,617,380 | 183.3 kb | Distal (>10kb) Multiome | 892 | |
| chr14:77,654,873–77,655,664 | 144.9 kb | Distal (>10kb) Multiome | 287 | |
| chr14:77,707,585–77,708,371 | 92.1 kb | Distal (>10kb) Multiome | 744 | |
| chr14:77,760,384–77,761,929 | 39.1 kb | Distal (>10kb) Multiome | 755 | |
| chr14:77,795,457–77,796,830 | 3.3 kb | Proximal (<10kb) | 117 | |
| chr14:77,799,937–77,800,798 | 120 bp | At TSS Multiome | 865 | |
| chr14:77,804,511–77,804,876 | 4.4 kb | Proximal (<10kb) | 44 | |
| chr14:77,965,921–77,966,514 | 166.1 kb | Distal (>10kb) Multiome | 258 | |
| chr14:77,980,545–77,981,614 | 181.0 kb | Distal (>10kb) Multiome | 329 | |
| chr14:78,029,563–78,030,313 | 229.8 kb | Distal (>10kb) Multiome | 227 |
Genomic view of the ADCK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.