Predicted to enable tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ADAT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:143,449,758–143,451,361 | 108 bp | At TSS Multiome | 1141 | |
| chr6:143,510,987–143,512,153 | 61.0 kb | Distal (>10kb) Multiome | 1071 | |
| chr6:143,536,309–143,537,965 | 86.6 kb | Distal (>10kb) Multiome | 577 | |
| chr6:143,598,354–143,599,128 | 148.2 kb | Distal (>10kb) Multiome | 303 | |
| chr6:143,677,404–143,678,655 | 227.3 kb | Distal (>10kb) Multiome | 774 | |
| chr6:143,746,106–143,747,905 | 296.8 kb | Distal (>10kb) Multiome | 594 |
Genomic view of the ADAT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.