This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ADAMTSL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTSL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTSL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:17,800,095–17,801,499 | 105.7 kb | Distal (>10kb) Multiome | 151 | |
| chr9:17,905,758–17,907,777 | 347 bp | At TSS Multiome | 352 | |
| chr9:18,437,407–18,439,158 | 532.1 kb | Distal (>10kb) Multiome | 315 | |
| chr9:18,472,975–18,473,358 | 740 bp | At TSS | 77 | |
| chr9:18,473,687–18,474,577 | 567.5 kb | Distal (>10kb) Multiome | 219 | |
| chr9:18,761,619–18,762,366 | 855.5 kb | Distal (>10kb) Multiome | 131 |
Genomic view of the ADAMTSL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.