This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for ADAMTS5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:26,842,972–26,847,283 | 122.2 kb | Distal (>10kb) Multiome | 698 | |
| chr21:26,856,178–26,856,869 | 109.1 kb | Distal (>10kb) Multiome | 107 | |
| chr21:26,965,256–26,966,609 | 96 bp | At TSS Multiome | 302 | |
| chr21:26,966,727–26,967,991 | 1.2 kb | Proximal (<10kb) | 282 | |
| chr21:27,025,101–27,026,890 | 60.5 kb | Distal (>10kb) Multiome | 212 | |
| chr21:28,516,848–28,517,501 | 1551.6 kb | Distal (>10kb) Multiome HiCAR | 284 |
Genomic view of the ADAMTS5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.