This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for ADAMTS17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:99,983,052–99,984,349 | 355.7 kb | Distal (>10kb) Multiome HiCAR | 293 | |
| chr15:100,330,270–100,330,478 | 8.7 kb | Proximal (<10kb) | 14 | |
| chr15:100,334,062–100,334,607 | 4.5 kb | Proximal (<10kb) | 46 | |
| chr15:100,334,998–100,335,219 | 3.9 kb | Proximal (<10kb) | 33 | |
| chr15:100,338,886–100,339,294 | at TSS | At TSS | 158 | |
| chr15:100,340,630–100,342,607 | 3.0 kb | Proximal (<10kb) Multiome | 629 | |
| chr15:100,349,411–100,350,616 | 11.0 kb | Distal (>10kb) Multiome | 588 | |
| chr15:100,601,704–100,603,366 | 263.3 kb | Distal (>10kb) Multiome | 808 | |
| chr15:100,878,673–100,880,993 | 540.5 kb | Distal (>10kb) Multiome HiCAR | 455 |
Genomic view of the ADAMTS17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.