This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for ADAMTS14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:70,381,835–70,383,091 | 289.8 kb | Distal (>10kb) Multiome | 693 | |
| chr10:70,403,687–70,404,709 | 268.4 kb | Distal (>10kb) Multiome | 788 | |
| chr10:70,439,787–70,443,007 | 230.0 kb | Distal (>10kb) Multiome | 501 | |
| chr10:70,455,031–70,455,839 | 217.1 kb | Distal (>10kb) Multiome | 196 | |
| chr10:70,478,010–70,479,323 | 193.8 kb | Distal (>10kb) Multiome | 492 | |
| chr10:70,672,118–70,672,962 | 30 bp | At TSS Multiome | 465 | |
| chr10:70,815,560–70,816,821 | 143.5 kb | Distal (>10kb) Multiome | 746 | |
| chr10:70,887,437–70,888,780 | 215.8 kb | Distal (>10kb) Multiome | 728 |
Genomic view of the ADAMTS14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.