Predicted to enable ATP binding activity. Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Located in centrosome and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ACTR8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACTR8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACTR8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:53,842,545–53,843,152 | 39.4 kb | Distal (>10kb) Multiome | 473 | |
| chr3:53,845,424–53,846,842 | 35.8 kb | Distal (>10kb) Multiome | 849 | |
| chr3:53,881,538–53,882,565 | 48 bp | At TSS Multiome | 818 | |
| chr3:53,891,162–53,892,300 | 9.8 kb | Proximal (<10kb) Multiome | 760 | |
| chr3:53,938,728–53,939,694 | 57.0 kb | Distal (>10kb) Multiome | 239 | |
| chr3:54,087,508–54,088,258 | 205.7 kb | Distal (>10kb) Multiome | 177 | |
| chr3:54,120,980–54,123,073 | 240.0 kb | Distal (>10kb) Multiome | 295 |
Genomic view of the ACTR8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.