This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ACTR1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACTR1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACTR1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:102,225,881–102,226,551 | 276.5 kb | Distal (>10kb) Multiome | 652 | |
| chr10:102,229,814–102,232,116 | 272.7 kb | Distal (>10kb) Multiome | 689 | |
| chr10:102,240,581–102,242,031 | 261.1 kb | Distal (>10kb) Multiome | 504 | |
| chr10:102,244,918–102,246,010 | 257.3 kb | Distal (>10kb) Multiome | 734 | |
| chr10:102,393,940–102,396,107 | 107.0 kb | Distal (>10kb) Multiome | 912 | |
| chr10:102,399,132–102,400,002 | 103.1 kb | Distal (>10kb) Multiome | 832 | |
| chr10:102,408,600–102,409,538 | 93.6 kb | Distal (>10kb) Multiome | 277 | |
| chr10:102,410,213–102,410,909 | 92.0 kb | Distal (>10kb) Multiome | 148 | |
| chr10:102,418,158–102,422,381 | 83.1 kb | Distal (>10kb) Multiome | 1097 | |
| chr10:102,422,562–102,423,126 | 79.8 kb | Distal (>10kb) Multiome | 721 | |
| chr10:102,431,859–102,432,863 | 70.1 kb | Distal (>10kb) Multiome | 828 | |
| chr10:102,449,444–102,451,250 | 53.0 kb | Distal (>10kb) Multiome | 810 | |
| chr10:102,454,792–102,455,588 | 47.7 kb | Distal (>10kb) Multiome | 159 | |
| chr10:102,460,805–102,462,064 | 41.3 kb | Distal (>10kb) Multiome | 665 | |
| chr10:102,501,628–102,503,235 | 520 bp | At TSS Multiome | 738 | |
| chr10:102,503,432–102,504,897 | 1.3 kb | Proximal (<10kb) Multiome | 684 | |
| chr10:102,641,824–102,646,130 | 142.4 kb | Distal (>10kb) Multiome | 1123 | |
| chr10:102,678,809–102,679,295 | 176.3 kb | Distal (>10kb) Multiome | 476 | |
| chr10:102,713,669–102,715,337 | 211.7 kb | Distal (>10kb) Multiome | 895 | |
| chr10:102,743,388–102,744,547 | 241.1 kb | Distal (>10kb) Multiome | 777 | |
| chr10:102,776,775–102,777,340 | 274.3 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the ACTR1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.