The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ACSBG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACSBG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACSBG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:78,077,036–78,077,991 | 157.0 kb | Distal (>10kb) Multiome | 552 | |
| chr15:78,130,851–78,132,005 | 103.1 kb | Distal (>10kb) Multiome | 769 | |
| chr15:78,148,893–78,150,142 | 85.3 kb | Distal (>10kb) Multiome | 746 | |
| chr15:78,241,018–78,241,399 | 6.5 kb | Proximal (<10kb) | 277 | |
| chr15:78,243,479–78,243,672 | 8.9 kb | Proximal (<10kb) | 54 | |
| chr15:78,264,436–78,265,112 | 30.0 kb | Distal (>10kb) Multiome | 241 | |
| chr15:78,299,130–78,299,874 | 65.1 kb | Distal (>10kb) Multiome | 798 | |
| chr15:78,303,744–78,304,214 | 69.4 kb | Distal (>10kb) Multiome | 287 | |
| chr15:78,340,100–78,340,745 | 105.7 kb | Distal (>10kb) Multiome | 194 | |
| chr15:78,437,554–78,438,897 | 203.6 kb | Distal (>10kb) Multiome | 918 | |
| chr15:78,506,965–78,508,087 | 272.9 kb | Distal (>10kb) Multiome | 674 |
Genomic view of the ACSBG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.