This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for ACP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:11,339,100–11,339,837 | 240.4 kb | Distal (>10kb) Multiome | 506 | |
| chr19:11,346,053–11,346,958 | 233.5 kb | Distal (>10kb) Multiome | 676 | |
| chr19:11,355,078–11,355,735 | 224.6 kb | Distal (>10kb) Multiome | 382 | |
| chr19:11,361,368–11,362,625 | 218.3 kb | Distal (>10kb) Multiome | 256 | |
| chr19:11,374,474–11,375,717 | 205.1 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,380,761–11,382,262 | 198.6 kb | Distal (>10kb) Multiome | 798 | |
| chr19:11,382,830–11,384,509 | 195.7 kb | Distal (>10kb) Multiome | 761 | |
| chr19:11,418,061–11,419,498 | 161.4 kb | Distal (>10kb) Multiome | 421 | |
| chr19:11,420,614–11,422,979 | 157.9 kb | Distal (>10kb) Multiome | 507 | |
| chr19:11,434,817–11,436,365 | 144.6 kb | Distal (>10kb) Multiome | 927 | |
| chr19:11,481,847–11,483,040 | 97.3 kb | Distal (>10kb) Multiome | 938 | |
| chr19:11,504,741–11,506,612 | 74.6 kb | Distal (>10kb) Multiome | 854 | |
| chr19:11,528,581–11,529,391 | 50.9 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,535,847–11,536,353 | 43.8 kb | Distal (>10kb) Multiome | 694 | |
| chr19:11,539,738–11,540,434 | 40.0 kb | Distal (>10kb) Multiome | 176 | |
| chr19:11,558,908–11,559,777 | 20.7 kb | Distal (>10kb) Multiome | 686 | |
| chr19:11,587,697–11,587,905 | 7.7 kb | Proximal (<10kb) | 294 | |
| chr19:11,597,206–11,598,107 | 17.5 kb | Distal (>10kb) Multiome | 914 | |
| chr19:11,639,337–11,640,481 | 59.8 kb | Distal (>10kb) Multiome | 660 | |
| chr19:11,694,497–11,695,341 | 115.0 kb | Distal (>10kb) Multiome | 608 | |
| chr19:11,737,998–11,739,422 | 159.0 kb | Distal (>10kb) Multiome | 704 | |
| chr19:12,484,131–12,485,387 | 904.8 kb | Distal (>10kb) Multiome HiCAR | 664 | |
| chr19:12,639,899–12,640,614 | 1060.3 kb | Distal (>10kb) Multiome HiCAR | 454 | |
| chr19:12,681,003–12,682,117 | 1101.4 kb | Distal (>10kb) Multiome HiCAR | 994 |
Genomic view of the ACP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.