The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for ACOX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACOX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACOX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:58,521,081–58,521,297 | 1.7 kb | Proximal (<10kb) | 417 | |
| chr3:58,522,214–58,522,604 | 382 bp | At TSS | 143 | |
| chr3:58,522,940–58,523,107 | at TSS | At TSS | 143 | |
| chr3:58,523,237–58,523,431 | 250 bp | At TSS | 162 | |
| chr3:58,529,612–58,529,809 | 6.6 kb | Proximal (<10kb) | 95 | |
| chr3:58,532,831–58,533,191 | 9.8 kb | Proximal (<10kb) | 381 |
Genomic view of the ACOX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.