The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ACO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:41,197,028–41,198,019 | 271.6 kb | Distal (>10kb) Multiome | 640 | |
| chr22:41,204,902–41,205,619 | 263.9 kb | Distal (>10kb) Multiome | 640 | |
| chr22:41,237,372–41,238,796 | 231.3 kb | Distal (>10kb) Multiome | 302 | |
| chr22:41,285,539–41,286,833 | 182.8 kb | Distal (>10kb) Multiome | 879 | |
| chr22:41,301,155–41,301,870 | 167.6 kb | Distal (>10kb) Multiome | 658 | |
| chr22:41,380,458–41,382,737 | 87.4 kb | Distal (>10kb) Multiome | 925 | |
| chr22:41,413,486–41,414,305 | 55.3 kb | Distal (>10kb) Multiome | 832 | |
| chr22:41,444,084–41,445,743 | 24.6 kb | Distal (>10kb) Multiome | 607 | |
| chr22:41,446,165–41,449,007 | 22.2 kb | Distal (>10kb) Multiome | 1188 | |
| chr22:41,468,341–41,469,602 | 202 bp | At TSS Multiome | 920 | |
| chr22:41,512,659–41,513,151 | 43.9 kb | Distal (>10kb) Multiome | 354 | |
| chr22:41,543,855–41,544,782 | 75.4 kb | Distal (>10kb) Multiome | 755 | |
| chr22:41,589,188–41,590,530 | 120.9 kb | Distal (>10kb) Multiome | 758 | |
| chr22:41,620,173–41,622,049 | 152.0 kb | Distal (>10kb) Multiome | 880 | |
| chr22:41,666,496–41,667,405 | 197.7 kb | Distal (>10kb) Multiome | 725 | |
| chr22:41,697,169–41,697,792 | 228.2 kb | Distal (>10kb) Multiome | 464 |
Genomic view of the ACO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.