Transcription factors with Perturb-seq knockdown data for ACCSLP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACCSLP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACCSLP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:7,332,167–7,332,648 | 9.4 kb | Proximal (<10kb) | 86 | |
| chr6:7,339,003–7,339,439 | 2.6 kb | Proximal (<10kb) | 170 | |
| chr6:7,347,359–7,348,352 | 5.3 kb | Proximal (<10kb) | 256 | |
| chr6:7,349,046–7,349,367 | 7.0 kb | Proximal (<10kb) | 5 |
Genomic view of the ACCSLP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.