This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for ACAD11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACAD11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACAD11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:132,382,239–132,383,246 | 277.5 kb | Distal (>10kb) Multiome | 203 | |
| chr3:132,416,687–132,418,425 | 242.7 kb | Distal (>10kb) Multiome | 733 | |
| chr3:132,644,811–132,645,749 | 14.8 kb | Distal (>10kb) Multiome | 191 | |
| chr3:132,654,384–132,654,673 | 5.1 kb | Proximal (<10kb) | 129 | |
| chr3:132,659,118–132,660,967 | 293 bp | At TSS Multiome | 872 | |
| chr3:132,721,513–132,723,554 | 62.6 kb | Distal (>10kb) Multiome | 756 |
Genomic view of the ACAD11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.