Enables microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Involved in nuclear chromosome segregation; protein K63-linked deubiquitination; and response to ischemia. Located in cytosol; microtubule cytoskeleton; and midbody. Part of BRISC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ABRAXAS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABRAXAS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABRAXAS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:124,565,553–124,566,190 | 235.9 kb | Distal (>10kb) Multiome | 253 | |
| chr10:124,743,297–124,744,966 | 57.4 kb | Distal (>10kb) Multiome | 546 | |
| chr10:124,791,269–124,792,470 | 10.0 kb | Proximal (<10kb) Multiome | 976 | |
| chr10:124,800,254–124,802,352 | 47 bp | At TSS Multiome | 821 | |
| chr10:124,916,459–124,917,959 | 115.0 kb | Distal (>10kb) Multiome | 843 | |
| chr10:125,048,088–125,048,633 | 246.5 kb | Distal (>10kb) Multiome | 344 |
Genomic view of the ABRAXAS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.