Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in dendrite morphogenesis; regulation of actin filament polymerization; and regulation of filopodium assembly. Predicted to be located in growth cone. Predicted to be active in several cellular components, including dendrite; filopodium tip; and lamellipodium. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ABITRAM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABITRAM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABITRAM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:107,459,805–107,460,688 | 1474.1 kb | Distal (>10kb) Multiome HiCAR | 143 | |
| chr9:107,465,452–107,466,627 | 1468.6 kb | Distal (>10kb) Multiome HiCAR | 320 | |
| chr9:108,933,334–108,934,940 | 188 bp | At TSS Multiome | 940 | |
| chr9:109,012,369–109,014,144 | 79.2 kb | Distal (>10kb) Multiome | 780 | |
| chr9:109,118,835–109,120,627 | 185.6 kb | Distal (>10kb) Multiome | 832 | |
| chr9:109,166,465–109,167,517 | 232.8 kb | Distal (>10kb) Multiome | 131 |
Genomic view of the ABITRAM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.