A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for ABHD16A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD16A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD16A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:31,403,046–31,404,269 | 299.7 kb | Distal (>10kb) Multiome | 796 | |
| chr6:31,441,682–31,442,105 | 261.5 kb | Distal (>10kb) Multiome | 316 | |
| chr6:31,462,703–31,463,323 | 240.2 kb | Distal (>10kb) Multiome | 352 | |
| chr6:31,497,638–31,498,615 | 205.3 kb | Distal (>10kb) Multiome | 613 | |
| chr6:31,541,205–31,542,816 | 161.2 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:31,546,485–31,547,136 | 156.5 kb | Distal (>10kb) Multiome | 589 | |
| chr6:31,547,301–31,547,742 | 155.7 kb | Distal (>10kb) Multiome | 762 | |
| chr6:31,580,713–31,581,330 | 122.3 kb | Distal (>10kb) Multiome | 745 | |
| chr6:31,619,744–31,621,435 | 82.8 kb | Distal (>10kb) Multiome | 1127 | |
| chr6:31,651,682–31,653,297 | 50.6 kb | Distal (>10kb) Multiome | 1113 | |
| chr6:31,660,325–31,660,941 | 42.5 kb | Distal (>10kb) Multiome | 892 | |
| chr6:31,664,725–31,666,373 | 38.4 kb | Distal (>10kb) Multiome | 1039 | |
| chr6:31,682,887–31,683,880 | 20.0 kb | Distal (>10kb) Multiome | 248 | |
| chr6:31,702,816–31,703,520 | 21 bp | At TSS Multiome | 875 | |
| chr6:31,713,576–31,714,641 | 10.8 kb | Distal (>10kb) Multiome | 171 | |
| chr6:31,728,852–31,730,814 | 26.9 kb | Distal (>10kb) Multiome | 979 | |
| chr6:31,739,236–31,740,741 | 36.6 kb | Distal (>10kb) Multiome | 1043 | |
| chr6:31,766,045–31,766,778 | 63.1 kb | Distal (>10kb) Multiome | 351 | |
| chr6:31,795,097–31,796,366 | 92.6 kb | Distal (>10kb) Multiome | 979 | |
| chr6:31,806,162–31,807,183 | 103.7 kb | Distal (>10kb) Multiome | 947 | |
| chr6:31,814,125–31,815,936 | 111.3 kb | Distal (>10kb) Multiome | 822 | |
| chr6:31,818,020–31,818,663 | 115.1 kb | Distal (>10kb) Multiome | 280 | |
| chr6:31,821,306–31,822,544 | 118.7 kb | Distal (>10kb) Multiome HiCAR | 714 | |
| chr6:31,826,770–31,828,135 | 124.2 kb | Distal (>10kb) Multiome HiCAR | 1000 | |
| chr6:31,834,277–31,835,371 | 131.4 kb | Distal (>10kb) Multiome | 1085 | |
| chr6:31,862,148–31,864,173 | 159.6 kb | Distal (>10kb) Multiome | 1118 | |
| chr6:31,896,965–31,898,037 | 194.3 kb | Distal (>10kb) Multiome | 654 | |
| chr6:31,901,114–31,902,643 | 198.9 kb | Distal (>10kb) Multiome | 826 | |
| chr6:31,958,527–31,959,598 | 255.8 kb | Distal (>10kb) Multiome | 953 | |
| chr6:31,971,421–31,972,872 | 269.0 kb | Distal (>10kb) Multiome | 1059 |
Genomic view of the ABHD16A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.