Predicted to enable lysophospholipase activity and monoacylglycerol lipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ABHD12B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD12B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD12B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:50,667,319–50,668,903 | 203.8 kb | Distal (>10kb) Multiome | 914 | |
| chr14:50,823,525–50,824,353 | 48.1 kb | Distal (>10kb) Multiome | 183 | |
| chr14:50,829,783–50,831,951 | 40.9 kb | Distal (>10kb) Multiome | 634 | |
| chr14:50,871,977–50,872,487 | at TSS | At TSS | 114 | |
| chr14:50,875,455–50,875,672 | 3.4 kb | Proximal (<10kb) | 336 | |
| chr14:50,943,178–50,945,258 | 72.5 kb | Distal (>10kb) Multiome | 823 | |
| chr14:51,093,327–51,096,214 | 223.2 kb | Distal (>10kb) Multiome | 700 |
Genomic view of the ABHD12B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.