This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for ABHD10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:111,852,502–111,853,012 | 126.3 kb | Distal (>10kb) Multiome | 110 | |
| chr3:111,853,492–111,855,490 | 123.9 kb | Distal (>10kb) Multiome | 162 | |
| chr3:111,858,752–111,861,061 | 119.4 kb | Distal (>10kb) Multiome | 807 | |
| chr3:111,978,499–111,979,684 | 28 bp | At TSS Multiome | 800 | |
| chr3:111,985,698–111,986,117 | 6.7 kb | Proximal (<10kb) | 7 | |
| chr3:111,998,552–111,999,758 | 20.1 kb | Distal (>10kb) Multiome | 325 | |
| chr3:112,048,832–112,049,452 | 70.1 kb | Distal (>10kb) Multiome | 163 | |
| chr3:112,085,739–112,087,192 | 107.4 kb | Distal (>10kb) Multiome | 690 | |
| chr3:112,126,419–112,126,878 | 147.7 kb | Distal (>10kb) Multiome | 150 | |
| chr3:112,136,789–112,137,394 | 158.1 kb | Distal (>10kb) Multiome | 233 |
Genomic view of the ABHD10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.