The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ABCG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:41,953,094–41,954,549 | 265.1 kb | Distal (>10kb) Multiome | 667 | |
| chr21:42,009,116–42,011,396 | 208.9 kb | Distal (>10kb) Multiome | 954 | |
| chr21:42,107,454–42,108,282 | 111.2 kb | Distal (>10kb) Multiome | 336 | |
| chr21:42,218,772–42,219,352 | 60 bp | At TSS Multiome | 258 | |
| chr21:42,226,604–42,226,809 | 7.5 kb | Proximal (<10kb) | 16 | |
| chr21:42,228,133–42,228,401 | 9.0 kb | Proximal (<10kb) | 304 | |
| chr21:42,234,400–42,235,305 | 15.8 kb | Distal (>10kb) Multiome | 427 | |
| chr21:42,495,806–42,497,032 | 277.3 kb | Distal (>10kb) Multiome | 588 | |
| chr21:42,513,219–42,514,906 | 294.6 kb | Distal (>10kb) Multiome | 484 |
Genomic view of the ABCG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.