ABCA7
ATP binding cassette subfamily A member 7 | ABCX

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

Developmental clusters: GC7
Biological processes 70 terms
ABC-type transporter activity (GO:0140359)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATPase-coupled intramembrane lipid carrier activity (GO:0140326)ATPase-coupled intramembrane lipid carrier activity (GO:0140326)ATPase-coupled transmembrane transporter activity (GO:0042626)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)amyloid-beta clearance by cellular catabolic process (GO:0150094)amyloid-beta formation (GO:0034205)amyloid-beta formation (GO:0034205)apolipoprotein A-I receptor activity (GO:0034188)apolipoprotein A-I receptor activity (GO:0034188)apolipoprotein A-I receptor activity (GO:0034188)apolipoprotein A-I-mediated signaling pathway (GO:0038027)cell junction (GO:0030054)cell surface (GO:0009986)cholesterol efflux (GO:0033344)cholesterol efflux (GO:0033344)cholesterol efflux (GO:0033344)cholesterol efflux (GO:0033344)cytoplasm (GO:0005737)early endosome membrane (GO:0031901)endoplasmic reticulum (GO:0005783)floppase activity (GO:0140328)floppase activity (GO:0140328)glial cell projection (GO:0097386)high-density lipoprotein particle assembly (GO:0034380)intracellular membrane-bounded organelle (GO:0043231)membrane (GO:0016020)memory (GO:0007613)negative regulation of MAPK cascade (GO:0043409)negative regulation of PERK-mediated unfolded protein response (GO:1903898)negative regulation of amyloid precursor protein biosynthetic process (GO:0042985)negative regulation of amyloid-beta formation (GO:1902430)negative regulation of endocytosis (GO:0045806)phagocytic cup (GO:0001891)phagocytic cup (GO:0001891)phosphatidylcholine floppase activity (GO:0090554)phosphatidylcholine floppase activity (GO:0090554)phosphatidylcholine floppase activity (GO:0090554)phosphatidylserine floppase activity (GO:0090556)phosphatidylserine floppase activity (GO:0090556)phosphatidylserine floppase activity (GO:0090556)phospholipid efflux (GO:0033700)phospholipid efflux (GO:0033700)phospholipid efflux (GO:0033700)phospholipid efflux (GO:0033700)phospholipid transfer activity (GO:0120014)phospholipid translocation (GO:0045332)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane raft organization (GO:0044857)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of amyloid-beta clearance (GO:1900223)positive regulation of cholesterol efflux (GO:0010875)positive regulation of engulfment of apoptotic cell (GO:1901076)positive regulation of phagocytosis (GO:0050766)positive regulation of phospholipid efflux (GO:1902995)positive regulation of protein localization to cell surface (GO:2000010)protein binding (GO:0005515)protein localization to nucleus (GO:0034504)regulation of amyloid precursor protein catabolic process (GO:1902991)regulation of amyloid precursor protein catabolic process (GO:1902991)regulation of lipid metabolic process (GO:0019216)ruffle membrane (GO:0032587)ruffle membrane (GO:0032587)transmembrane transport (GO:0055085)visual learning (GO:0008542)
Expression (TPM)
ABCA7 — as a Regulated Gene

TFs regulating ABCA7 0 TFs

Transcription factors with Perturb-seq knockdown data for ABCA7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCA7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ABCA7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCA7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:796,668–798,362 242.9 kb Distal (>10kb) Multiome 956
chr19:821,294–822,728 218.0 kb Distal (>10kb) Multiome 254
chr19:861,664–863,223 177.9 kb Distal (>10kb) Multiome 530
chr19:892,703–893,746 146.9 kb Distal (>10kb) Multiome 715
chr19:917,038–918,169 122.3 kb Distal (>10kb) Multiome 711
chr19:924,743–926,242 114.4 kb Distal (>10kb) Multiome 796
chr19:927,058–927,629 112.7 kb Distal (>10kb) Multiome 362
chr19:982,565–983,215 57.3 kb Distal (>10kb) Multiome 590
chr19:984,046–985,154 55.6 kb Distal (>10kb) Multiome 829
chr19:1,000,142–1,000,881 39.8 kb Distal (>10kb) Multiome 399
chr19:1,020,611–1,022,069 18.7 kb Distal (>10kb) Multiome 1017
chr19:1,026,155–1,026,856 13.6 kb Distal (>10kb) Multiome 598
chr19:1,027,770–1,028,926 11.6 kb Distal (>10kb) Multiome 584
chr19:1,030,704–1,030,919 9.2 kb Proximal (<10kb) 168
chr19:1,039,648–1,040,400 115 bp At TSS Multiome 684
chr19:1,040,481–1,041,402 1.1 kb Proximal (<10kb) Multiome 556
chr19:1,044,758–1,045,598 5.2 kb Proximal (<10kb) Multiome 402
chr19:1,061,840–1,062,923 22.4 kb Distal (>10kb) Multiome 204
chr19:1,063,045–1,065,722 24.7 kb Distal (>10kb) Multiome 681
chr19:1,066,682–1,067,587 27.1 kb Distal (>10kb) Multiome 489
chr19:1,071,107–1,071,721 31.0 kb Distal (>10kb) Multiome 178
chr19:1,081,317–1,083,172 42.3 kb Distal (>10kb) Multiome 484
chr19:1,094,985–1,095,654 55.4 kb Distal (>10kb) Multiome 671
chr19:1,103,487–1,105,654 63.9 kb Distal (>10kb) Multiome 849
chr19:1,112,029–1,112,884 72.2 kb Distal (>10kb) Multiome 294
chr19:1,113,014–1,114,139 73.5 kb Distal (>10kb) Multiome 690
chr19:1,122,934–1,123,720 83.1 kb Distal (>10kb) Multiome 231
chr19:1,173,441–1,174,438 134.1 kb Distal (>10kb) Multiome 682
chr19:1,194,370–1,194,985 154.5 kb Distal (>10kb) Multiome 531
chr19:1,205,175–1,206,374 165.5 kb Distal (>10kb) Multiome 746
chr19:1,237,080–1,238,434 198.0 kb Distal (>10kb) Multiome 430
chr19:1,239,513–1,242,539 201.6 kb Distal (>10kb) Multiome 889
chr19:1,244,253–1,244,857 204.5 kb Distal (>10kb) Multiome 590
chr19:1,247,981–1,252,501 211.0 kb Distal (>10kb) Multiome 1136
chr19:1,259,185–1,262,955 219.3 kb Distal (>10kb) Multiome 1070
chr19:1,265,280–1,270,235 229.2 kb Distal (>10kb) Multiome 1171
chr19:1,274,423–1,276,502 235.6 kb Distal (>10kb) Multiome 967
chr19:1,285,317–1,286,108 245.7 kb Distal (>10kb) Multiome 277

Genome Browser

Genomic view of the ABCA7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:786,668 – 1,296,108
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact