The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for A4GALT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = A4GALT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of A4GALT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:42,437,555–42,438,618 | 282.9 kb | Distal (>10kb) Multiome | 501 | |
| chr22:42,444,134–42,444,723 | 276.4 kb | Distal (>10kb) Multiome | 574 | |
| chr22:42,499,840–42,501,072 | 220.4 kb | Distal (>10kb) Multiome | 356 | |
| chr22:42,519,544–42,520,134 | 201.0 kb | Distal (>10kb) Multiome | 330 | |
| chr22:42,553,476–42,554,267 | 167.0 kb | Distal (>10kb) Multiome | 514 | |
| chr22:42,581,750–42,582,381 | 138.7 kb | Distal (>10kb) Multiome | 290 | |
| chr22:42,614,291–42,616,423 | 105.5 kb | Distal (>10kb) Multiome | 1280 | |
| chr22:42,648,972–42,649,906 | 71.4 kb | Distal (>10kb) Multiome | 625 | |
| chr22:42,662,035–42,662,743 | 58.5 kb | Distal (>10kb) Multiome | 468 | |
| chr22:42,717,276–42,717,600 | 3.3 kb | Proximal (<10kb) | 160 | |
| chr22:42,720,289–42,721,050 | 33 bp | At TSS Multiome | 297 | |
| chr22:42,856,601–42,857,716 | 136.5 kb | Distal (>10kb) Multiome | 938 | |
| chr22:42,964,987–42,965,486 | 244.3 kb | Distal (>10kb) Multiome | 332 | |
| chr22:43,014,433–43,015,934 | 294.4 kb | Distal (>10kb) Multiome | 845 |
Genomic view of the A4GALT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.