{
  "data": {
    "id": "DE-1.1",
    "type": "module",
    "module_id": 250,
    "module_name": "DE-1.1",
    "display_name": "DE-1.1",
    "aliases": [],
    "source": "hotspot_submodule",
    "size": 61,
    "title": "Cytosolic ribosome and protein biosynthesis",
    "description": "This 61-gene module is enriched for ribosomal proteins and translation machinery, including MIF, RACK1, FTH1, EEF1A1, and TPT1, with strong enrichment for cytosolic ribosome structure, ribosomal subunits, and cytoplasmic translation processes. Knockdown of TAF10, SOX17, and ZC3H3 activates this module. Knockdown of CTBP1, SMAD3, and GATA4 represses this module.",
    "description_extended": "This 61-gene module is robustly enriched for components of the cytosolic ribosome and the protein biosynthetic machinery, featuring key genes such as MIF, RACK1, FTH1, EEF1A1, and TPT1. The enrichment spans structural ribosomal proteins, rRNA binding functions, and both cytoplasmic and general translation processes, indicating this module represents core translational capacity. Knockdown of the transcription factors TAF10, SOX17, and ZC3H3 upregulates module expression, suggesting these factors normally suppress translation machinery. Conversely, knockdown of CTBP1, SMAD3, and GATA4 downregulates the module, implying these factors normally support ribosomal gene expression during endoderm differentiation.",
    "n_genes": 61,
    "n_enrichment_terms": 1172,
    "n_tf_regulators": {"perturbation": 40, "binding": 1872},
    "child_submodules": [],
    "parent_module": "DE-1"
  },
  "links": {"self": "https://huangfulab.com/endoderm-perturbseq/api/v1/submodule/DE-1.1", "html": "https://huangfulab.com/endoderm-perturbseq/module/DE-1.1", "parent": "https://huangfulab.com/endoderm-perturbseq/api/v1/module/DE-1"}
}