{
  "data": {
    "id": "DE-1",
    "type": "module",
    "module_id": 13,
    "module_name": "DE-1",
    "display_name": "DE-1",
    "aliases": [],
    "source": "hotspot_supermodule",
    "size": 2012,
    "title": "Ribosomal subunit and translation machinery",
    "description": "This 2012-gene module includes APOE, KRAS, GSTP1, HMGB1, and SOD1, and is highly enriched for ribosomal subunits, ribosomal structure, translation, and protein biosynthesis, with additional enrichment in mitochondrial inner membrane and proton transporter activity. Knockdown of KLF6 and GRHL2 activates this module. Knockdown of CTBP1, SOX11, SOX4, TBX3, and ZNF628 represses this module.",
    "description_extended": "This 2012-gene module is dominated by ribosomal and translation-related genes, including APOE, KRAS, GSTP1, HMGB1, and SOD1, with very strong enrichment for ribosomal subunits, ribosomal structural function, translation, and protein biosynthesis processes. The presence of mitochondrial inner membrane and proton transporter terms suggests a secondary cellular respiration component. Knockdown of KLF6 and GRHL2 upregulates this module, suggesting these factors normally suppress ribosomal and translational genes during endoderm differentiation. Conversely, knockdown of CTBP1, SOX11, SOX4, TBX3, and ZNF628 downregulates the module, indicating these factors support ribosomal biogenesis and translation capacity, possibly to maintain protein synthesis rates needed for early differentiation.",
    "n_genes": 2012,
    "n_enrichment_terms": 3675,
    "n_tf_regulators": {"perturbation": 15, "binding": 1934},
    "child_submodules": [
      "DE-1.1",
      "DE-1.10",
      "DE-1.11",
      "DE-1.12",
      "DE-1.13",
      "DE-1.14",
      "DE-1.15",
      "DE-1.16",
      "DE-1.17",
      "DE-1.18",
      "DE-1.19",
      "DE-1.2",
      "DE-1.20",
      "DE-1.21",
      "DE-1.22",
      "DE-1.23",
      "DE-1.24",
      "DE-1.25",
      "DE-1.26",
      "DE-1.27",
      "DE-1.28",
      "DE-1.29",
      "DE-1.3",
      "DE-1.30",
      "DE-1.31",
      "DE-1.32",
      "DE-1.33",
      "DE-1.34",
      "DE-1.35",
      "DE-1.36",
      "DE-1.37",
      "DE-1.38",
      "DE-1.39",
      "DE-1.4",
      "DE-1.40",
      "DE-1.41",
      "DE-1.42",
      "DE-1.43",
      "DE-1.44",
      "DE-1.45",
      "DE-1.46",
      "DE-1.47",
      "DE-1.48",
      "DE-1.49",
      "DE-1.5",
      "DE-1.50",
      "DE-1.51",
      "DE-1.52",
      "DE-1.53",
      "DE-1.54",
      "DE-1.55",
      "DE-1.56",
      "DE-1.57",
      "DE-1.6",
      "DE-1.7",
      "DE-1.8",
      "DE-1.9"
    ],
    "parent_module": null
  },
  "links": {"self": "https://huangfulab.com/endoderm-perturbseq/api/v1/module/DE-1", "html": "https://huangfulab.com/endoderm-perturbseq/module/DE-1"}
}